What is the fastest way to lose karma in Fallout 3? Beyond that, it’ll basically allow/deny you from getting certain followers to join you based on karma requirements, though you can work to adjust your karma level if it comes to that. Bad karma, a different group of NPCs come after you. Good karma, a group of NPCs come after you. Each team has their own perks and benefits. In the game aspect, there are basically two teams.
In an actual bad karma playthrough, more people would want you dead. In actuality, a good karma playthrough would be “better” because if people like you, nobody would want you dead (for the most part).